The Alpha Magnetic Spectrometer (AMS) is a unique cosmic-ray detector that has been attached to the International Space Station since 2011. On the cover of the latest issue, NASA astronaut Drew Morgan, photographed on 2 December, is seen installing a new coolant system that will extend the lifetime of AMS until the end of the decade. A full report on the unprecedented mission will appear on cerncourier.com following a final extravehicular activity by Drew and his colleagues scheduled for mid-January, and offer a taste of the experiment’s latest results – which contradict conventional understanding. Meanwhile, in this issue we investigate an intriguing anomaly in nuclear decays seen by the “Atomki” experiment, learn about the wider value of anomalies to phenomenologists, talk to theorist John Ellis about the past, present and future of the field, and explore high-level attempts to solve the flavour puzzle. KATRIN’s quest for the neutrino mass, outreach for visually impaired audiences, careers in visual effects and the latest results from the LHC experiments are among other highlights of this first issue of the 2020s.