In 1968, Herbert Fröhlich predicted an analogue of Bose–Einstein condensation in biological macromolecules with a range of vibrational frequencies, which could lead to a macroscopic condensation of energy into the lowest-frequency mode. This would be remarkable not only for its appearing in a biological context, but also for not requiring low temperatures. Now, Gergely Katona of the University of Gothenburg in Sweden and colleagues have finally shown this condensation in a crystallised egg protein (lysozyme) subjected to 0.4 THz radiation. X-ray crystallography shows a non-thermal change in electron density with a micro- to millisecond thermalisation timescale, which can only be explained by Fröhlich condensation. This is the first experimental confirmation of the effect, and may have far-reaching implications for biology.