Eric Betzig, of the Janelia Research Campus of the Howard Hughes Medical Institute in Virginia, shared the 2014 Nobel Prize for Chemistry for the invention of super-resolution microscopy. Now, he and his colleagues have taken the technique a step further. They have extended light-sheet microscopy to use utrathin light sheets from 2D optical lattices to scan plane by plane through a specimen to build up a 3D image at up to 1000 frames per second. The reduced illumination also has the advantage of causing minimal specimen damage, so cells and small embryos can be filmed as they go about their lives, as the researchers demonstrate for 20 biological processes covering four orders of magnitude in space and time.